The prospects for building image sensors, for the current consumer markets, in America are depressing. Fortuitously the image sensor space is entering the 4th disruption in its evolution. The last 3 disruptions primarily focused on taking ‘pretty pictures’ for human consumption, evaluation, and storage. The disruption coming will focus on moving machine vision to main stream. Smart homes, offices, cars, or devices, AR/MR, biometrics and crowd monitoring all need to run image data through a processor without human viewing to activate actionable responses. The opportunity this presents is massive, but as the growth efficiencies come into play the solutions will become specialized. This discussion will review the opportunities, why the entrenched players may not be operating at so great an advantage, and what will be needed to take advantage of the emerging shift within imaging.